Toxicological studies of aqueous root extract of Euphorbia lateriflora (Schum and Thonn) in rats
Usman M.M*, Sule M. S and Gwarzo M.Y
The effect of administration of graduated dose of aqueous root of Euphorbia lateriflora on ALT, AST, ALP, bilirubin, total protein, creatinine and urea in rats was determined to ascertain the toxic effects on the liver and kidney. There was a significantly higher (p<0.05) ALT activity and significantly lower urea level in group administered with 100 mg/kg of aqueous root extract compared to the control. There was a significantly higher (p<0.05) ALT, AST, and level of bilirubin in group administered with 250 mg/kg aqueous root extract compared to the control. The result suggest a possible hepatotoxic effect of root extract of Euphorbia lateriflora after administration of 100 mg/kg and 250 mg/kg, there was no possible kidney malfunction. The result of the oral acute toxicity study shown that Euphorbia lateriflora have oral LD50 above 5000 mg/kg. Histopathological lesions were observed in liver and kidney after acute toxicity study.