2014, Vol. 2, Issue 2, Part B

author(s)
Mohsen Mazidi, Mohsen Nematy, Sara Baghban Taraghdari, Mohammad Soukhtanloo, Mahmoud Hosseini, Hassan Rakhshandeh, Abdolreza Norouzy

abstract
Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Ghrelin is an orexigenic peptide which is secreted from stomach. Recent studies have shown this hormone can improve the nutrition status of patients with cachexia. Coriandrum sativum is known as an orexigenic herb in Iranian traditional medicine. Little evidence is gathered about its orexigenic effect and its mechanism; therefore, in the current study the possible orexigenic effect of hydroalcoholic extract ofCoriandrum sativum was evaluated. To measure the ghrelin level in rats, two groups of 6 male Wistar rats were randomly selected. One group received the orexigenic dose ofCoriandrum sativum and the other received distilled water by gavage. Rats were anaesthetized, blood samples were collected and plasma total ghrelin level was measured by using ELISA. The results suggest that Coriandrum sativum has no effect on level of the ghrelin hormone. Future studies are needed to determine the contribution of the other mechanisms to orexigenic effect of this plant.