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Journal of Medicinal Plants Studies
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ISSN Print: 2394-0530, ISSN Online: 2320-3862, NAAS Rating: 3.53

NAAS Rating: 3.53 NEW

Journal of Medicinal Plants Studies

2014, Vol. 2, Issue 5, Part A
Antileishmanial activity of Hyssopus officinalis, Tussilago farfara, Carum copticum extracts in comparison with Glucantime in Iran

Fatemeh Tabatabaie, Alireza keighobadi, Mohsen golestani, Narges shahmohammad, Mehran Voosoogh, Mehri Noori, Kobra Mokhtarian and Fatemeh Maleki

Leishmania is transmitted by sandflies that ingest the parasite in the amastigote phase resident within macrophages, then inoculate the promastigote phase into body hosts. The present study was conducted to evaluate the in vitro effects of alcoholic extracts of plants on L. major. The extract of aerial parts of plants were obtained by maceration. Thein vitro experiments were performed on promastigotes to assess anti Leishmanial activity of the extracts using glucantime as a reference. The extract of plants and glucantime solutions for biological testing were prepared in PBS atseveral concentration, respectively. All experiments were repeated at least three times in duplicate. For the extract of plants and glucantime, the concentration-response curve was plotted, from which IC50 values were determined also MTT assay was done. The different concentrations resulted in different optical densities or inhibitory percentages (P<0.05) so that extract of plants were effective against L. major in vitro. The Findings of this study indicates that these plants are effective against L. major in vitro.
Reducing optical density caused by antileishmanial activity of different concentrations of Drug and Carum copticum on the in vitro growth of L. major promastigotes.
Fig.: Reducing optical density caused by antileishmanial activity of different concentrations of Drug and Carum copticum on the in vitro growth of L. major promastigotes.
Pages : 12-18 | 1036 Views | 24 Downloads
How to cite this article:
Fatemeh Tabatabaie, Alireza keighobadi, Mohsen golestani, Narges shahmohammad, Mehran Voosoogh, Mehri Noori, Kobra Mokhtarian and Fatemeh Maleki. Antileishmanial activity of Hyssopus officinalis, Tussilago farfara, Carum copticum extracts in comparison with Glucantime in Iran. Journal of Medicinal Plants Studies. 2014; 2(5): 12-18.
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