2016, Vol. 4, Issue 1, Part A

author(s)
Vitthalrao B Khyade

abstract
Mulberry, Morus alba (L) is the significant plant at the Malegaon Sheti Farm of Agricultural Development Trust, Baramati. The mulberry leaves are mainly utilized for feeding the larval instars of silkworm, Bombyx mori (L). They are also commonly used to prepare traditional dessert among peoples of Baramati for a long time. Water was used as an extraction agent by the peoples in this area. This extracted leaves were used by the peoples of Baramati because it has natural color, flavor and fragrance properties. In the present attempt, the leaves of mulberry, Morus alba (L) (Variety: Baramatiwali) were extracted by using 80% methanol in the laboratory. The extracted content was analyzed and found to be high in antioxidant activity of phenolic compound. The result shows that the extracted content of the leaves of mulberry, Morus alba (L) (Variety: Baramatiwali) had high amount of total phenolic compound (44.66µg of GAE/mg of fresh weight). The plants secondary metabolites normally play role in cancer treatment. Cytotoxicity activity of the extracted leaves of mulberry, Morus alba (L) (Variety: Baramatiwali) was evaluated on MCF-7 (Breast cancer cell line), HT-29 (colorectal cancer cell line), and WRL-68 (normal liver cell line), and the results show that, cytotoxicity activity (IC50 values 78.87µg/ml, 77.50µg/ml, and 78.29µg/ml, respectively). Methanolic extract of the leaves of mulberry, Morus alba (L) (Variety: Baramatiwali) mulberry leaf had antioxidant effects, which may suggest its use as food supplement for cancer patients.