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Journal of Medicinal Plants Studies
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ISSN Print: 2394-0530, ISSN Online: 2320-3862, NAAS Rating: 3.53

NAAS Rating: 3.53 NEW

Journal of Medicinal Plants Studies

2016, Vol. 4, Issue 1, Part B
Anti-inflammatory efficacyrnof the rhizome of Zingiber zerumbet – an in vitro study usingrnTHP1 cell line

Madhavankutty Jyothilakshmi, Mathew Jyothis, Mukalel Sankunni Latha

Inflammation arises as arnprotective mechanism but persistent inflammation is irritating, harmful and canrnresult in chronic diseases. Zingiber zerumbet is a perennial herbrnbelonging to the family Zingiberaceae. Anti-inflammatory effect of thernmethanolic extract of the rhizome of Zingiber zerumbet collected from therndistrict of Kottayam, Kerala was studied using THP1 cell line. The cell linernwas induced with lipopolysaccharide and the inhibitory effect of the extract onrnthe activity of cyclooxygenase, lipoxygenase, myeloperoxidase and nitric oxidernsynthase was tested. The extract possessed the ability to inhibitrncyclooxygenase, lipoxygenase, myeloperoxidase and nitric oxide synthase inducedrnby lipopolysaccharide. This showed multiple mode of action of the extract inrnexecuting anti-inflammatory effect. Hence the methanolic extract of the rhizomernof Zingiber zerumbet can be used to develop drugs for various allergicrnand inflammatory disorders in traditional as well as modern medicine.
Percentage inhibition of cellular nitrite level by methanolic extract of the rhizome of Zingiber zerumbet and diclofenac sodium
Fig.: Percentage inhibition of cellular nitrite level by methanolic extract of the rhizome of Zingiber zerumbet and diclofenac sodium
Pages : 103-106 | 650 Views | 25 Downloads
How to cite this article:
Madhavankutty Jyothilakshmi, Mathew Jyothis, Mukalel Sankunni Latha. Anti-inflammatory efficacyrnof the rhizome of Zingiber zerumbet – an in vitro study usingrnTHP1 cell line. 2016; 4(1): 103-106.
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