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Journal of Medicinal Plants Studies
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ISSN Print: 2394-0530, ISSN Online: 2320-3862, NAAS Rating: 3.53

NAAS Rating: 3.53 NEW

Journal of Medicinal Plants Studies

2016, Vol. 4, Issue 4, Part D
Antimicrobial and antiradical activities of ethyl acetate extracts from endophytic fungi isolated from Cameroonian medicinal plants

Toghueo RMK, Zeuko’o Menkem E, Mbekou Kanko MI, Jesus Marie Arc-en-Ce, Ngo Mback N, Eke P, Vázquez de Aldana BR, Íñigo Z and Fekam Boyom F

The antimicrobial activity of extracts from endophytic fungi were determined using microdilution method. The 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity was used for antiradical activity and the chemical profile of promising extracts was analyzed using HPLC-DAD, UPLC/MS-QTOF and HPLC/MSn Electrospray Ion Trap. The Minimum Inhibitory Concentration on yeasts and bacteria ranged from 0.019 to 5 mg/mL. Extract from T. atroviride was most active against yeasts (MIC from 0.019 to 5mg/ml) and P. chermesinum (MIC from 0.625 to 0.019 mg/ml) was against bacteria. The best radical scavenging activity was found with Diaporthe sp extract (%I from 9.929 to 41.134%). The chemical composition of extracts from T. atroviride, P. chermesinum and Diaporthe sp showed the presence of 8, 12 and 10 compounds respectively amongst which Genipinic acid, Citreomantanin, Dermoglaucin, Alternariol-5-methylether, Ascochitine, Aflatoxicol, Ascorbic acid, 4-deoxybostrycin, Bionectriamide B, Nivalenol, and Trisdechloronornidulin were identified. These results indicate that metabolites produced by endophytic fungi found in Cameroonian medicinal plants are potent source of bioactive compounds.
Pages : 290-295 | 1010 Views | 40 Downloads
How to cite this article:
Toghueo RMK, Zeuko’o Menkem E, Mbekou Kanko MI, Jesus Marie Arc-en-Ce, Ngo Mback N, Eke P, Vázquez de Aldana BR, Íñigo Z and Fekam Boyom F. Antimicrobial and antiradical activities of ethyl acetate extracts from endophytic fungi isolated from Cameroonian medicinal plants. Journal of Medicinal Plants Studies. 2016; 4(4): 290-295.
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