2017, Vol. 5, Issue 2, Part D

author(s)
Okereke SC, Chukwudoruo CS and Nwaokezie CO

abstract
The study evaluated antioxidant potentials of Laportea aestuans and chemopreventive potentials on urinary inflammatory markers using albino rats. The rats were fed with 10%, 30% and 50% Laportea aestuans. Results indicates a reduction in nitric oxide levels compared to control (P<0.05) while concentration of polyphenols in urine were significant with increased percentage of Laportea aestuans supplemented diet. This study also showed reductive potencies of Laportea aestuans in the concentration of protein in urine. Results also showed an increase in the activities of CyP1A1 microsomal enzymes in the test groups compared to control (P<0.05). The activities of Glutathion S- transferase, Quinone oxidoreductase and Thioredoxin reductase increased significantly in all the test samples with increasing percentage of Laportea aestuans compared to control. This is indicative of the potential health benefit of Laportea aestuans in chemoprevention. On this basis, Laportea aestuans have shown to inhibit the inflammatory mechanisms underlying disease activation, that precipitate major clinical manifestations of cancer by affecting altered mechanisms of inflammation and tissue proliferation.