Cultivation, phytochemical and in vitro anti-plasmodium activity of Artemisia annua L. (Asteraceae)
Abubakar US, Yusuf KM, Abdullahi MS, Abdu GT, Abdulrazak A, Muhammad S, Binta IK, Osodi FA and Aliyu I
The chemical synthesis of Artemisinin for the production of Artemisinin-based Combination Therapies (ACTs) is complex, uneconomical and produces low yields, thus, the main source of Artemisinin is the Chinese plant, Artemisia annua. The present study was aimed to determine the adaptability, phytochemical constituents and in vitro anti-plasmodium activity of hexane and aqueous leaf extracts of A. annua cultivated in Kano State, Nigeria. The phytochemical analysis revealed the presence of cardiac glycosides, steroids, terpenoids, alkaloids and flavonoids in both extracts, while saponins, tannins, phenolic compounds and anthraquinones were only detected in the aqueous extract. The in vitro anti-plasmodium screening showed that both extracts have anti-plasmodium activity; with aqueous extract having the highest activity at the concentration of 10, 5, 2.5 and 1.25 mg/ml which was statistically significant (P≤0.05) when compared to the positive control. The study has shown that Kano soils may be suitable for the commercial cultivation of this important medicinal plant.
Abubakar US, Yusuf KM, Abdullahi MS, Abdu GT, Abdulrazak A, Muhammad S, Binta IK, Osodi FA and Aliyu I. Cultivation, phytochemical and in vitro anti-plasmodium activity of Artemisia annua L. (Asteraceae). Journal of Medicinal Plants Studies. 2018; 6(4): 151-155.