Comparison of sambiloto (Andrographis paniculata (Burm.f.) Nees) and Salam (Syzygium polyanthum (wight) walp) extract mixture with simvastatin on ferritin concentration in dyslipidemic patients
Andry Syahreza, Santi Syafril and Dharma Lindarto
Background: Dyslipidemia is one of many risk factor in cardiovascular diseases and significantly correlated with increased inflammation marker, including ferritin concentration. Synthetic antidyslipidemic drugs, such as Simvastatin, may decrease ferritin concentration, even without many supporting study. However, long term use of synthetic drugs could cause side effects, so that phytopharmaca is becoming to consideration. The mixture of sambiloto and Salam extracts reported decreasing proinflammatory cytokines, cholesterol, and triglyceride. We try to compare the effect of sambiloto and Salam extract mixture with simvastatin on Ferritin concentration in dyslipidemic patients in this study.
Method: This clinical trial use prospective design with double blinded random sampling that involved 30 patients divided by two groups (simvastatin and sambiloto and Salam extract mixture).
Result: Ferritin concentration before therapy compared to after examination was decreased but it was statistically insignificant ((150, 09 + 104, 95 vs 133, 63 + 94, 77) ng/dL; p = 0,079) not only in study group but also in control group ((172, 44 + 162, 7 vs 160, 75 + 164,7) ng/dL; p = 0,325). The decrease of ferritin in study group was bigger than the control group, but it was statistically insignificant ((17, 2 + 45,24 vs 11,69 + 53,15) ng/dL; p = 0,221).
Conclusion: The mixture of sambiloto (Andrographis paniculata) and Salam (Syzygium polyanthum) extract decreased ferritin concentration bigger than simvastatin, but statistically insignificant.