2019, Vol. 7, Issue 1, Part B

Aim: To evaluate the Anticonvulsant property of Cuminum cyminum in albino rats.

Methodology: This experimental study conducted on albino rats by MES method. Adult albino rats of either sex (100-150g) were divided into three groups for each parameter under study. Group I consisting of six animals, served as control and received distilled water. Group II subdivided into three groups II-A, II-B, II-C, consisting of six animals each, received Cuminum cyminum in three doses of 300mg, 750 mg, 1000mg per orally respectively. Group III subdivided into three groups III-A, III-B, III-C, consisting of six animals each, received the Phenytoin in three doses per orally.

Result: Cuminum cyminum decreased extension period. Although the extension period was not significant [P > 0.05] in 300 mg per kg dose, while the extension period was highly significant [P < 0.001] in higher doses (750, 1000mg per kg).

Conclusion: Cuminum cyminum is having Anticonvulsant property in the albino rat. However further study needed to find out its mechanism of actions and chemical constitutes responsible for these activities.