2019, Vol. 7, Issue 1, Part B

Background: Trigonella foenum-graecum seeds have been suggested to have potential anti-diabetic effects.

Aim: To study effects of fenugreek seeds aqueous extract on glycemic status, insulin resistance, homeostatic model assessment, safety parameters and antioxidant superoxide dismutase in Type 2 Diabetes Mellitus (T2DM) subjects and its correlation.

Methods: Randomized case-control study consisting of control (n=30), T2DM (n=30) and T2DM patients with adjunct therapy (n=30) of 1.32g fenugreek seeds aqueous extract for 3 months. Blood glucose, HbA1C, lipid profile, liver and kidney function tests were done using chemistry autoanalyzer. Insulin and C-peptide were done on chemiluminescence. Malondialdehyde and superoxide dismutase were analysed using spectrophotometer.

Results: Glucose, HbA1C and malondialdehyde were significantly lowered after 3 months in group receiving adjunct therapy. Insulin resistance, anthropometric and antioxidant status were improved while haemoglobin, alanine transaminase and renal functions remained unaltered.

Conclusion: Aqueous extract of fenugreek is effective and safe to control hyperglycemia in T2DM.