Ameliorative effect of Tecomella undulata stem bark on the cadmium chloride induced splenomegaly and its associated changes in wistar rats
Navneet Nagpal, Gurpreet Kaur Gill, Amandeep Singh and Reni Kapoor
Tecomella undulata (TU) was traditionally used in managing various disorders associated with spleen and liver dysfunctioning. In the present study, an aqueous extract of TUstem bark was prepared and evaluated for its protective effect on morphological, histological and haematological changes associated with splenomegaly induced by oral administration of cadmium chloride to Wistar rats. Animals were divided into eight groups having five animals in each group. Group I animals received standard food 50 g daily, Group II animals were administered with cadmium chloride with 50 g of food and Groups III-VIII was treated with TU extract (200 - 1200 mg/kg/day dose) along with group II treatment. The blood sample was taken from rats of all the groups by puncturing the heart tissue on 31st day for haematological studies, and then rats of the entire groups were killed. Spleen was examined for morphological and histological changes. Statistical analysis of the haematological, morphological and histological data of spleen among different groups revealed that cadmium chloride feeding caused splenomegaly, but when the aqueous extract of TU at the dose > 600 mg/kg/day was administered along with cadmium chloride, the spleen size and complete blood profile remains normal. Moreover, there was no significant change observed in the histology of spleen of TU extract treated animals of groups V-VIII.
Navneet Nagpal, Gurpreet Kaur Gill, Amandeep Singh and Reni Kapoor. Ameliorative effect of Tecomella undulata stem bark on the cadmium chloride induced splenomegaly and its associated changes in wistar rats. Journal of Medicinal Plants Studies. 2019; 7(4): 203-206.