2014, Vol. 2, Issue 6, Part A

The methanolic extract of Croton sparciflorus was studied for the cardioprotective activity using Isoproterenol induced myocardial infarction in wistar albino rats. Methanolic extract of this plant showed significant cardioprotective effect by lowering the serum levels of various biochemical parameters like CPK, LDH and transaminases in the selected model. The results obtained in the present work are in turn with histopathological examinations of heart tissue sections and are comparable with the standard cardioprotective drug. The results also suggests that the biologically active phytoconstituents such as flavonoids, glycosides, alkaloids present in the methanolic extract of plant which is confirmed from the qualitative analysis may be responsible for the significant cardioprotective activity.