Brahmi Ghrita is an important formulation used in treatment of learning and memory disorders. It contains Brahmi (Bacopa monneri), Vacha (Acorus calamus), Kushtha (Saussurea lappa), Shankhapushpi (Convolvulus pluricaulis) and old clarified butter (Puran Ghrita). Here an attempt was done to assess the effect of Brahmi Ghrita on Serum creatine and Serum Urea in experimental animals. For this purpose, Brahmi Ghrita was prepared as per standard Sneha paka process mentioned in our classics. For experimental study one of those animals were selected which have high Serum creatine and Serum Urea level. These animals were divided in three groups, among them one was an experimental control group and animals of the other two groups were treated with Brahmi Ghrita in a dose of 400 and 800 mg/kg body weight of rats. After period of one month haematological parameters, Serum creatine and Serum Urea was examined. It was observed that Brahmi Ghrita significantly decreases Serum creatine in dose dependent manner and have no adverse effect was observed on haematological parameters.