2015, Vol. 3, Issue 3, Part A

author(s)
Thagriki Dluya, Daniel Dahiru, Yaduma Gaiuson. W

abstract
The in vitro study aimed at determining the antioxidant, scavenging activity and lipid peroxidation of aqueous root extract of Pakia biglobosa, Anogeissus leiocarpus and Moringa oleifera on oxidatively stressed human erythrocytes. The investigation shows that Pakia biglobosa aqueous root extract at varying concentrations (1.5mg/ml, 3mg/ml and 6mg/ml) shows significant antioxidant activity (13.94±0.05, 23.65±0.07 and 20.69±0.17) respectively compared to the control sample (11.80±0.10). Anogeissus leiocarpus aqueous root extract malondialdehyde formation at concentrations (3mg/ml and 6mg/ml) also shows scavenging activity and antioxidant potential in protecting the cell from oxidative stress (19.49±0.13 and 31.61±0.07) respectively while at 1.5mg/ml concentration of the extract it shows no significant effect compared to the control sample. Analysis of Moringa oleifera aqueous root extract shows protective effect at 6mg/ml (17.46±0.13) only while concentrations (1.5mg/ml and 3mg/ml) showed no antioxidant and scavenging activity thus rendering the cell vulnerable to oxidative stress. Hence root extract of these medicinal plants have been used traditionally and are employed for the treatment of metabolic and nonmetabolic diseases.