The ameliorative effect of Petroselinum crispum (parsley) on some diabetes complications

Hanan A. Soliman; Nadia A Eltablawy; Mona S Hamed

The ameliorative effect of Petroselinum crispum (parsley) on some diabetes complications

author(s)
Hanan A. Soliman, Nadia A Eltablawy, Mona S Hamed

abstract
This study is aimed to evaluate the hypolipidemic effect of parsleyaqueous extract (PAE) and its effect on heart tissue of diabetic rats. Diabetes induced by subcutaneous injection of streptozotocin (STZ). Sixty diabetic rats were equally divided into four groups: control diabetic rats, diabetic rats treated with PAE and/or gliclazide. In addition, sixty normal rats were equally divided into four control groups: control non-treated rats, normal rats treated with PAE and/or gliclazide. The experiment lasted for 45 days. STZ injection induced a significant increase in plasma total cholesterol, triglycerides, low-density lipoprotein levels and glutathione transferase activity in association with a significant decrease in plasma high-density lipoprotein, whole blood glutathione and serum homocysteine levels. Expression of caspase-3 in cardiac tissue was affected by STZ injection. In conclusion, administration of PAE significantly attenuates the hyperlipidemia, overcomes the oxidative stress and improves heart tissue of diabetic rats.

Immunohistochemical detection of caspase-3 expression in heart tissue of the tested groups. Each bar represents area % of caspase-3 immunopositivity/field (mean of 6 fields Â± SE). The heart of different capital letters means significant differences between groups. ANOVA test followed by DuncanÊ¼s multiple comparisons between groups at P < 0.05 were employed.

Fig.: Immunohistochemical detection of caspase-3 expression in heart tissue of the tested groups. Each bar represents area % of caspase-3 immunopositivity/field (mean of 6 fields Â± SE). The heart of different capital letters means significant differences between groups. ANOVA test followed by DuncanÊ¼s multiple comparisons between groups at P < 0.05 were employed.

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How to cite this article:

Hanan A. Soliman, Nadia A Eltablawy, Mona S Hamed. The ameliorative effect of Petroselinum crispum (parsley) on some diabetes complications. J Med Plants Stud 2015;3(4):92-100.

2015, Vol. 3, Issue 4, Part B

The ameliorative effect of Petroselinum crispum (parsley) on some diabetes complications

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