There are several components isolated from plants grown in Mediterranean environment exhibiting significant beneficial properties against a variety of disorders related to lipid or glucose metabolism. In this context, plant species (e.g. Salvia officinalis, Rosmarinus officinalis, Lavandula stoechas, Melissa officinalis, Mentha piperita, Thymus vulgaris,Origanum majorana, Sideritis raeseri, Ocimum basilicum, Pistacia lentiscus, Crocus sativus, Daucus carota) may act against lipid or carbohydrate metabolic disorders through their antioxidant, anti-inflammatory or other properties, or due to the beneficial actions of their compounds. New horizons are very promising, since these plant species have been used both in Traditional Medicine and in current clinical practice