Objective: The extracts obtained from the leaves of Cotinus coggygria Scop. (Anacardiaceae) were investigated for their ability to inhibit clinically relevant fungal pathogens. Methods: Ethanol (EtOH), ethyl acetate (AcOEt) and dicholoromethane (DCM) were screened against six Candida species (C. albicans ATCC 10231, C. tropicalis ATCC 13803, C. guilliermondii ATCC 6260, C. krusei ATCC 20298, C. glabrata ATCC 2001, C. parapsilosis ATCC 22019), and two Cryptococcus species (C. neoformans ATCC 90112 and C. laurentii ATCC 34142) by the microbroth dilution method. Results: The plant displayed activity against all yeast cultures tested. Greater activity was observed for the EtOH, AcOEt and DCM extracts of C. coggygria against C. guilliermondii, C. krusei and C. laurentii, with MIC values of 30, 60 and 60 µg/mL, respectively. Further separation of active principle from the potent plant will be useful for the control of Candida and Cyptococcus species. Conclusion: Our findings support the use of C. coggygria in traditional medicine for the treatment against the yeast infections.