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Journal of Medicinal Plants Studies
  • Printed Journal
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P-ISSN: 2394-0530, E-ISSN: 2320-3862

2016, Vol. 4, Issue 4, Part D

Pleiotropic activity of Hypericum perforatum L.

Kotsiou A, Seferos N, Michael Hudu and Tesseromatis C

Hypericum perforatum L. (St John's wort) is a medicinal plant since Hippocrates era, due to its anti-inflammatory and wound/burn healing properties. Its main constituents are flavonoid aglycones (quercetin, luteolin, kaempferol), biflavonoids (apigenin, skeleton) and glycosides (hyperoside, hypericin, hyperforin isoquercitrin and quercitrin).
In addition to its wound healing properties, Hp extract reversed the arthritic symptoms in experimental Freunds adjuvant arthritis presenting its antiinflammatoty effect.
Hypericum perforatum extract exerts antidepressive and antiatherogenic activity. Furthermore it posseses oestrogen-mimetic activity, as it has been shown in a model of forced intensive swimming stress where Hp administration increased bone mass density. Moreover lipid parameters were beneficially modified under Hp in the same experimental model of stress.
Studies showed that Hp LI 160 treatment has a beneficial effect on most menopausal symptoms and potentially prevents obesity in a menopause experimental model in rats, where Hp treatment compared to estradiol administration seems to have similar activity.
Pages : 256-258 | 1768 Views | 191 Downloads
How to cite this article:
Kotsiou A, Seferos N, Michael Hudu, Tesseromatis C. Pleiotropic activity of Hypericum perforatum L.. J Med Plants Stud 2016;4(4):256-258.
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