Hypoglycemic and glucose tolerance activity of standardized extracts Ficus deltoidea varieties in normal rats
Halimatul Saadiah Mohammad Noor, Nor Hadiani Ismail, Noraini Kasim, Rozaini Mohd Zohdi and Abd. Manaf Ali
Ficus deltoidea or its local Malaysian name “Mas Cotek” is a popular herbal plant with a long history of the use among the Malays to control blood sugar levels. Assessment of the seven different varieties of F. deltoidea available in the Peninsular Malaysia for in vitro α-glucosidase inhibitory has revealed different levels of activity warranting further in vivo studies. The acute toxicity test showed no signs of morbidity or mortality and the median lethal dose (LD50) of the extracts for all varieties was higher than 2000 mg/kg body weight. Histopathological assessments of the kidney and liver did not show any abnormalities. Administration of the extracts at two different doses, 250 and 500 mg/kg in normal rats indicate F. deltoidea did not produce severe hypoglycemia. However, in oral glucose tolerance test (OGTT), the leaves extracts showed significant reduction in plasma glucose level after 30 minutes, albeit to different levels with the most effective being F. deltoidea var. intermedia.
Halimatul Saadiah Mohammad Noor, Nor Hadiani Ismail, Noraini Kasim, Rozaini Mohd Zohdi, Abd. Manaf Ali. Hypoglycemic and glucose tolerance activity of standardized extracts Ficus deltoidea varieties in normal rats. J Med Plants Stud 2016;4(5):275-279.