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Journal of Medicinal Plants Studies
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ISSN Print: 2394-0530, ISSN Online: 2320-3862, NAAS Rating: 3.53

NAAS Rating: 3.53 NEW

Journal of Medicinal Plants Studies

2017, Vol. 5, Issue 1, Part A
Chemical constituents and anti-inflammatory activity of essential oils of Datura stramonium L.

Aderonke S Aboluwodi, Opeyemi N Avoseh, Oladipupo A Lawal, Isiaka A Ogunwande and Abdulateef A Giwa

The chemical constituents and anti-inflammatory activity of essential oils of Datura stramonium L. (family Solanaceae) are being reported. The essential oils were obtained by separate hydrodistillation of the air-dried and pulverized leaves and seeds of D. stramonium. The essential oils were analysed by means of gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). (72.5%) was identified as the main constituent of the leaf oil. However, citral (26.5%), 4,8-dimethyl-3,8-dien-2-one (11.2%), sesquirosefuran (11.1%) and geraniol (10.5%) were identified as the major constituents in the seed oil. The anti-inflammatory action was determined on fresh egg albumins over 4 h by measurement of baseline paw diameters. Oral administration of essential oils at a dose of 2% showed significant (p<0.001) anti-inflammatory properties in the albumin-induced test model in rats compared to the control, while activity as compared to the standard drug, Diclofenac (100 mg/kg), was only significant P<0.05 for the duration of the analysis. Oils from the leaves inhibited inflammation beyond 4 h post treatment with percentage inhibition ranging between 22 to 95% throughout the period of analysis. The potent anti-inflammatory activity of essential oils of D. stramonium may serves as exploitation of D. stramonium in treating various inflammatory diseases.
Pages : 21-25 | 1395 Views | 110 Downloads
How to cite this article:
Aderonke S Aboluwodi, Opeyemi N Avoseh, Oladipupo A Lawal, Isiaka A Ogunwande, Abdulateef A Giwa. Chemical constituents and anti-inflammatory activity of essential oils of Datura stramonium L.. J Med Plants Stud 2017;5(1):21-25.
Journal of Medicinal Plants Studies
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