Protective effect of Brassica oleracea juice against Ketamine-induced stereotypic behaviours in mice
Monu Yadav, Milind Parle and Mamta Sachdeva Dhingra
Now-a-days, stressful life style and unhealthy food habits may produce various neuropsychiatric disorders. WHO has promoted the investigation of therapeutic effects of dietary supplements and medicinal plants for psychotic disorders due to lack of safety with allopathic drugs. Brassica oleracea (Brassicaceae) commonly known as cabbage, is widely used in our daily diet and well known for tremendous source of nutrients all over the world. In spite of this there is no CNS report on cabbage. Therefore, we have selected this plant and studied against Ketamine-induced stereotypic behaviours in mice. Haloperidol and Olanzapine were used as standard drugs as standard drugs in the present study. Brassica oleracea juice (4% v/v, 8% v/v and 16 v/v, p.o.) for significantly diminished the Ketamine induced falling, turning head bobbing and weaving behaviors in mice. These findings indicate that Brassica oleracea juice possesses protective effective in Ketamine induced stereotypic behaviours. Thus consumption of cabbage on regular basis through daily diets would help in protecting us from developing mental problems.