2017, Vol. 5, Issue 1, Part C

author(s)
Kumari Binita, Veena Sharma and Savita Yadav

abstract
Diabetes mellitus (DM) type II is a long term endocrine metabolic disorder due to disturbances in metabolism of carbohydrate, fat, protein and characterized by hyperglycemia. It is a multi-factorial disease and the current strategy used for the treatment is a combination of an insulin secretagogue and an insulin sensitizer. These synthetic medicines generally target single pathway to control the blood glucose level. Therefore, despite of better result to control of diabetes mellitus, these synthetic therapeutic approaches have serious and several side effects. Due to low toxicities and cost effectiveness natural products are comparatively safe and good source of effective antidiabetic agents. Syzygium cumini and its seed a member of Myrtaceae family acquire potential role in regulating diabetes mellitus and its seeds are moderately rich in protein (6.3-8.5%) and contains so many other phytochemicals. It gives a new therapeutic paradigm as anti-hyperglycemic agent either due to a single component or combination of different components present in the seed. Present review gives an idea about the multiple mode of action by S. cumini seeds to control diabetes mellitus and its related complications clinically and pharmacologically.