2017, Vol. 5, Issue 1, Part E

author(s)
Ramdan B, Amakran A, Bakrim N, Vannier B, Greche H and Nhiri M

abstract
Antioxidant and anti-glycation properties of nine Moroccan plants of the Lamiaceae family used in traditional medicine, has been evaluated by after extraction by hot (HAE) or cold (CAE) maceration and by ethanol (EE). Anti-glycation activity was performed on BSA-Methylglyoxal system and was measured by fluorescence and native electrophoresis. The EE yielded the highest levels of polyphenols and flavonoids at Origanum Compactum. The same extract showed a strong antioxidant activity with IC₅₀ = 75.5±0.63 µg/ml, followed by Rosmarinus officinalis with IC₅₀ = 99.7±0.47 µg/ml, and Calamintha officinalis with IC₅₀ = 111±0.5 µg/ml. All plants studied showed dose dependent anti-glycation activity, with a pronounced effect recorded in Thymus satureioides. The aqeous extracts showed a correlation between polyphenols and flavonoids witch was in turn correlated with antioxidant activity. No correlation was observed between anti-glycation and anti-oxidation/polyphenol content. The Lamiaceae family is therefore a rich promoter source in phenolic compounds, and presents both an antioxidant and anti-glycation activity.