Anti-glycation and radical scavenging activities of hydro-alcohol and aqueous extracts of nine species from Lamiaceae family
Ramdan B, Amakran A, Bakrim N, Vannier B, Greche H and Nhiri M
Antioxidant and anti-glycation properties of nine Moroccan plants of the Lamiaceae family used in traditional medicine, has been evaluated by after extraction by hot (HAE) or cold (CAE) maceration and by ethanol (EE). Anti-glycation activity was performed on BSA-Methylglyoxal system and was measured by fluorescence and native electrophoresis. The EE yielded the highest levels of polyphenols and flavonoids at Origanum Compactum. The same extract showed a strong antioxidant activity with IC50 = 75.5±0.63 µg/ml, followed by Rosmarinus officinalis with IC50 = 99.7±0.47 µg/ml, and Calaminthaofficinalis with IC50 = 111±0.5 µg/ml. All plants studied showed dose dependent anti-glycation activity, with a pronounced effect recorded in Thymus satureioides. The aqeous extracts showed a correlation between polyphenols and flavonoids witch was in turn correlated with antioxidant activity. No correlation was observed between anti-glycation and anti-oxidation/polyphenol content.The Lamiaceae family is therefore a rich promoter source in phenolic compounds, and presents both an antioxidant and anti-glycation activity.
Ramdan B, Amakran A, Bakrim N, Vannier B, Greche H, Nhiri M. Anti-glycation and radical scavenging activities of hydro-alcohol and aqueous extracts of nine species from Lamiaceae family. J Med Plants Stud 2017;5(1):331-345.