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Journal of Medicinal Plants Studies
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ISSN Print: 2394-0530, ISSN Online: 2320-3862, NAAS Rating: 3.53

NAAS Rating: 3.53 NEW

Journal of Medicinal Plants Studies

2017, Vol. 5, Issue 2, Part A
Analgesic and non-ulcerogenic activities of the aqueous extract of the aerial parts of Eremomastax speciosa Hochst (Acanthaceae) in mice

Mezui Christophe, Tchinda Fokoua Serges Herve, Amang Andre Perfusion, Malepa Meda Ginette Blanche and Tan Paul

To avoid the adverse effects (ulcerogenic activity for exemple) of nonsteroidal anti-inflammatory drugs (NSAIDs) while curing pain, some people use medicinal plants. This study investigated the analgesic and non-ulcerogenic activities of the aqueous extract of dried ground aerial parts of Eremomastax speciosa Hochst (Acanthaceae) in mice. The analgesic action was assayed in two experimental models: acetic acid and formalin; and the non-ulcerogenic activity by the observation of the gastric mucosa five hours after administration of different treatments. The aqueous extract of Eremomastax speciosa dose-dependently reduced the number of abdominal contractions induced by intraperitoneal injection of acetic acid, with inhibition percentages of 12.13%, 44.74% and 91.40% respectively for doses 100mg/kg, 200mg/kg (p<0.01) and 400mg/kg (p<0.001). During the second phase of the pain induced by formalin, the aqueous extract of Eremomastax speciosa significantly decreased (p<0.001) the time of licking and lifting of the leg, with inhibition percentages of 71.08%, 73.26% and 84.61% respectively for doses 100mg/kg, 200mg/kg and 400mg/kg. Unlike indomethacin, the aqueous extract of Eremomastax speciosa did not cause gastric ulcer, but at doses 200mg/kg and 400mg/kg it have induced an increase (p<0.001) in mucus secretion, with percentages of 65.10% and 65.51% respectively compared to positive control. These results show that aqueous extract of Eremomastax speciosa would possess analgesic and non-ulcerogenic properties.
Pages : 06-10 | 841 Views | 50 Downloads
How to cite this article:
Mezui Christophe, Tchinda Fokoua Serges Herve, Amang Andre Perfusion, Malepa Meda Ginette Blanche, Tan Paul. Analgesic and non-ulcerogenic activities of the aqueous extract of the aerial parts of Eremomastax speciosa Hochst (Acanthaceae) in mice. J Med Plants Stud 2017;5(2):06-10.
Journal of Medicinal Plants Studies
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