2017, Vol. 5, Issue 2, Part E

author(s)
Bhupesh Kumar Vema, Alok Mukerjee, Amita Verma, Shanti Bhushan Mishra and Alka Verma

abstract
The present study aimed to evaluate the effect of 50% ethanolic extract of Asparagus racemosus whole plant extract (ARE) on Phenylbutazone induced chronic gastric damage in experimental rats. Animals were induced for gastric ulcer with Phenylbutazone (100mg/kg bodyweight) and treated orally with ARE (250 and 500 mg/kg bodyweight). The effective dose i.e. 500 mg/kg elicited a maximum reduction in lesion index. The gastroprotective effect of ARE was assessed from the levels of different physicochemical parameters. The levels of DNA, protein bound carbohydrate complexes-hexose, hexoseamine, sialic acid, fucose in gastric juice were assessed. A significant reduction (p<0.001) in lesion index was observed in ulcer induced animals treated with plant extract compared to control group. A significant increase was observed in pH, protein bound carbohydrate complexes, nucleic acids with a significant decrease in volume of gastric juice, free and total acidity, pepsin concentration and acid output. From the data presented in this study it could be concluded that 50% ethanolic extract of Asparagus racemosus whole plant extract (ARE) acts as a gastroprotective agent.