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Journal of Medicinal Plants Studies
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ISSN Print: 2394-0530, ISSN Online: 2320-3862, NAAS Rating: 3.53

NAAS Rating: 3.53 NEW

Journal of Medicinal Plants Studies

2017, Vol. 5, Issue 2, Part E
Preclinical screening of Antiulcer activity of Asparagus racemosus extract on phenylbutazone induced ulceration in experimental animals

Bhupesh Kumar Vema, Alok Mukerjee, Amita Verma, Shanti Bhushan Mishra and Alka Verma

The present study aimed to evaluate the effect of 50% ethanolic extract of Asparagus racemosus whole plant extract (ARE) on Phenylbutazone induced chronic gastric damage in experimental rats. Animals were induced for gastric ulcer with Phenylbutazone (100mg/kg bodyweight) and treated orally with ARE (250 and 500 mg/kg bodyweight). The effective dose i.e. 500 mg/kg elicited a maximum reduction in lesion index. The gastroprotective effect of ARE was assessed from the levels of different physicochemical parameters. The levels of DNA, protein bound carbohydrate complexes-hexose, hexoseamine, sialic acid, fucose in gastric juice were assessed. A significant reduction (p<0.001) in lesion index was observed in ulcer induced animals treated with plant extract compared to control group. A significant increase was observed in pH, protein bound carbohydrate complexes, nucleic acids with a significant decrease in volume of gastric juice, free and total acidity, pepsin concentration and acid output. From the data presented in this study it could be concluded that 50% ethanolic extract of Asparagus racemosus whole plant extract (ARE) acts as a gastroprotective agent.
Pages : 348-352 | 784 Views | 23 Downloads
How to cite this article:
Bhupesh Kumar Vema, Alok Mukerjee, Amita Verma, Shanti Bhushan Mishra, Alka Verma. Preclinical screening of Antiulcer activity of Asparagus racemosus extract on phenylbutazone induced ulceration in experimental animals. J Med Plants Stud 2017;5(2):348-352.
Journal of Medicinal Plants Studies
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