2017, Vol. 5, Issue 4, Part A

author(s)
Mariana Nathuê Lôbo Prata, Cristina da Costa Oliveira, Ives Charlie-Silva, Thiago R Lima Romero and Andrea de Castro Perez

abstract
Diabetes is characterized by the absence of insulin or impairment of its action, which consequently lead to chronic hyperglycemia. Numerous complications emerge as a consequence of this metabolic alteration, resulting in complications of the circulatory system, vascular endothelium lesions and, consequently, the appearance of an inflammatory process and secondary diseases. Our objective is to review the anti-inflammatory action of resveratrol in chronic complications caused by Diabetes Mellitus. Several studies indicate that its anti-inflammatory action is due to the inhibition of several pro-inflammatory pathways and consequently the reduction of pro-inflammatory markers such as cytokines, chemokines and adhesion molecules. Resveratrol was able to reduce the inflammatory effects caused by Diabetes Mellitus, and improved nephropathy, neuropathy, hepatopathy, retinopathy, insulitis, among others, being a potential pharmacological tool and/or medicament.