2017, Vol. 5, Issue 6, Part A

author(s)
Ghanya Al-Naqeb

abstract
The study was performed to assess the anti-ulcer activity of Caralluma flava methanolic extract against ethanol induced gastric ulcer in rats model. A acute toxicity and antioxidant activities of Caralluma flava extract was evaluated. Acute toxicity of the Caralluma flava extract was evaluated with a single dose administered orally to rats in a dosage of 3g/kg for 2 weeks. Result showed that the extract was effective antioxidant towards DPPH radical and the scavenging activity was approximately nearly from the ascorbic acid. Acute toxicity test up to 3 g/kg of this extract did not display any toxicological effect.. The treated rats with Caralluma flava at 500 mg/kg, produced antiulcer effect in rats with a preventive index of 68.37 %. In conclusion, this study shows that of Caralluma flava extract was nontoxic up to 3g/kg and showed antiulcer properties. The antiulcer activity is exerted, possibly, via its high antioxidant activity.