2017, Vol. 5, Issue 6, Part A

author(s)
Ghanya Al-Naqeb

abstract

The hypoglycemic effect of the aqueous extract of Caralluma Flava N.E.Br leaves in streptozotocin-induced diabetic rats (STZ) was investigated. Mineral content, phenolic and flavonoid contents of Caralluma Flava leaves were investigated with the antioxidant activity. Results indicated that the Caralluma Flava dried leaves samples showed to be rich source of many macro and microelements. The obtained results show that the concentration of total phenol contents in the extract was 8.56 mg/g. The total flavonoid content was 2.87 mg/g. Serum glucose levels were significantly decreased in the Caralluma Flava treated rats in a dose dependent manner in comparison to the STZ diabetic control. Liver superoxide dismutase catalase and glutathione peroxidase levels were apparently increased in the Caralluma Flava treated rats at 0.2 and 0.5 g/kg compared to STZ diabetic control. In conclusion, it is illustrated that the Caralluma Flava extract showed hypoglycemic effect and antioxidant effect on the streptozotocin-induced diabetic rats.