Hematological and biochemical indices on subchronic administration of Setaria megaphylla (Steud) T. Dur and sphinx (Poaceae)root extract on rats
John Akpan Udobang and Jude Efiom Okokon
Background: Setaria megaphylla (Steud) T. Dur and Schinz (Poaceae), is a medicinal plant popularly used South-South Nigeria to treat malaria, hemorrhoids, urethritis, inflammation, diabetes, fevers and various pains(Udobang, Okokon and Etuk, 2016) .The persistent and consistent use of Setaria megaphylla by thelocals to treat various ailments therefore necessitated this investigation of its effects on blood.
Objectives: This work was therefore designed to investigate the effects of Setaria megaphylla ethanol root extract on hematological and biochemical parameters during sub chronic toxicity administration.
Methodology: The effects of Setaria megaphylla ethanol root extract (150, 300, 450 mg/kg) on hematological and biochemical indices (liver and kidney functions) in rats were investigated for using standard procedures.
Results: There was non-significant effects on the hematological and biochemicalparameters during sub chronic toxicity investigation.
Conclusions: The findings of this study revealed that S. megaphylla ethanol root extract exhibited negligible toxic effects.
John Akpan Udobang, Jude Efiom Okokon. Hematological and biochemical indices on subchronic administration of Setaria megaphylla (Steud) T. Dur and sphinx (Poaceae) root extract on rats. J Med Plants Stud 2017;5(6):81-85.