Honey, the world’s oldest sweetener, was the major sweetener until the sugarcane was cultivated on a large scale in the new world. Since ancient time honey has been using for its medicinal properties in many cultures. Pure honey chiefly contains dextrose and levulose together with water, in which these are at first dissolved. Most of the elements found in human body are present in honey in small quantity. In this review, we have described the constituents of honey and examine the information available that is supported by laboratory or clinical studies in which honey has shown positive results for the improvement of human health.