Oral glucose tolerance tests with methanolic extract of fruits of Musa textilis Nee
Anju Faridi Lopa, Khoshnur Jannat, Abdul Hamid and Mohammed Rahmatullah
In previous studies we have observed that methanol extracts of fruit skins of various types of cultivated banana species (Musa sapientum, Musa seminifera and Musa textilis) can improve glucose tolerance in glucose-loaded mice. The objective of this study was to evaluate the oral glucose tolerance efficacy of methanol extract of fruits of Musa textilis. Oral glucose tolerance test (OGTT) was done to evaluate glucose tolerance. In oral glucose tolerance tests, methanol extract of fruits of Musa textilis (MEMTF) significantly and dose-dependently reduced blood glucose levels in glucose-loaded mice by 10.3, 15.9, and 19.7%, respectively, at doses of 100, 200 and 400 mg each per kg body weight in mice. By comparison, a standard antihyperglycemic drug, glibenclamide reduced blood glucose levels by 39.3% at a dose of 10 mg per kg. The results suggest that MEMTF, although not as effective as glibenclamide, can still improve glucose tolerance and serve as an effective means for reducing blood glucose levels in persons with elevated blood glucose.