Role of Arjuna bark containing polyherbal formulation on oxidative stress parameters in hyperlipidemic chick model
T Anoosha and R Umadevi
Oxidative stress plays a major role in initiation and progression of hyperlipidaemia-induced atherosclerosis. Standard pharmacotherapy of dyslipidemia includes treatment with HMG Co-A reductase inhibitors, anion exchange resins, fibrates, nicotinic acid and its derivatives. While, the pathophysiological processes involved in hyperlipidemia leading to atherosclerosis have to be modulated, since, none of these drugs (except statins) till date has other pharmacological effects than causing hypolipidemia. Many plants are of global attention, with significant antioxidant, anti inflammatory and antilipidemic activity. Surprisingly their combined formulation and its effect in lipid lowering and inflammation have not been investigated. A study was carried out to investigate the influence of polyherbal formulation on certain oxidative stress parameters in hyperlipidemic chick model, which will help in further exploration of similar effects in human conditions.