2018, Vol. 6, Issue 6, Part B

author(s)
Vijender Singh, Charu Pahuja, Mohammed Ali and Shahnaz Sultana

abstract
Syzygium aromaticum L. (Myrtaceae), known as clove, is an aromatic dried flower bud grown in India and other tropical countries. It is aromatic, analgesic, antiseptic, spasmodic and stimulant and used to relieve cough, indigestion, toothache, arthritis, rheumatism and to manufacture perfumes, soaps and toothpastes. This research is principally focused on evaluating the effect of the flower bud on some acnegenic pathogens and anti-inflammatory and anti-oxidant activities. The GC-MS analysis of the clove bud essential oil showed the presence of eugenol (55.6%) as a major volatile constituents followed by eugenol acetate (12.5%), chavicol (6.5%), methyl acetate (5.9%), β-caryophyllene (5.2%) and α- caryophyllene (4.9%). The essential oil (1 %, v/v) exhibited significant antibacterial activity against Propionibacterium acne (17.8 mm) and Staphylococcus epidermis (16.8 mm) using Clindamycin as a standard. The essential oil showed an excellent scavenging activity against DPPH radical relative to Vitamin C (standard) at P<0.05. Dose dependent anti-inflammatory response was observed with increasing concentration of the clove bud oil. However, the essential oil (1%, v/v) exhibited significant effect comparable results to that of Diclofenac taken as reference standard. These observations justify the use of clove for the treatment of acne and pimples due to its marked antimicrobial, anti-oxidant and anti-inflammatory activities.