2018, Vol. 6, Issue 6, Part B

author(s)
M Bhavya, M Ramya, N Nagarjun, Nagarathna Amresh and Balasubramanian Sathyamurthy

abstract
Dengue is a mosquito-borne systemic viral infection caused by any of the four antigenically related dengue viruses (DENV).The dengue virus belongs to the Flaviviridae family of viruses that cause diseases in humans.A virtual screening analysis of phytochemical structures with dengue virus protein targets has been carried out using a molecular docking approach with Vins vinifera seeds. Grapes (Vitis vinifera) are believed to have health benefits due to their antioxidant activity and polyphenols. In this study we examined the binding affinities of 14 ligands with seven non structural Dengu viral proteins through In Silico methods like virtual screening and docking process which showed that compound F and compound N had high binding efficiencies with these proteins along with the type of hydrogen bonds and their respective amino acid residues at their docked sites.