2019, Vol. 7, Issue 1, Part A

In vivo antisalmonellal activity was assessed by the blood culture method on Wistar rats infected by S. Typhi (ATCC 6539), and oxidative stress biochemical parameters (superoxide dismutase, catalase, glutathione, malondialdehyde, nitric oxide) were evaluated after treatment. Phytochemical screening was performed to justify these activities.

The hydroethanolic leaves extract of Adenia lobata at different doses (5. 45 and 90 mg/kg of body weight) resulted in the healing of infected rats between the eighth and twelfth day of treatment. Extract treatment reduced malondialdehyde levels and increased SOD, catalase, glutathione, and nitric oxide levels in infected rats by normalizing some of this content compared to neutral controls. Phytochemical analysis revealed the presence of flavonoids, alkaloids, steroids, tannins, phenols, saponins, anthocyanins, triterpenes and anthraquinones in the hydroeyhanolic leaves extract of Adenia lobata.

These results show that the hydroeyhanolic leaves extract of Adenia lobata cures typhoid fever and reduces the state of oxidative stress caused by S. typhi during infection.