Evaluation of anti-inflammatory and analgesic activity of methanolic extract of Berberis lycium Royle
Suhail Ahmad Parra, Kalpesh Gaur, Ashok Dashora and Mohammad Imran Rather
Objectives: The aim of study was to investigate the anti-inflammatory and analgesic effects of methanolic extract of the shade dried fruits of Berberis lycium by oral administration at doses of 250 and 500 mg/kg of body weight in healthy Wistar albino rats.
Methods: The extract was studied for its anti-inflammatory activity in carrageenan-induced and histamine induced hind paw edema in rats and the linear paw circumference was measured at 0, 30, 60, 90 and 120 min. after the administration of phlogistic agent. The methanolic extract was also evaluated for analgesic activity using Eddy’s hot plate and Haffner’s tail-clip method in Wistar albino rats. The reaction time was taken as the parameter for the evaluation of analgesic activity at time intervals 0, 30, 60, 90 and 120 min. respectively.
Key findings: The methanolic extract of Berberis lycium, significantly (p<0.05) reduced carrageenan-induced and histamine induced paw edema in rats. The methanolic extract has also shown analgesic activity as evidenced by increase in the reaction time by Eddy’s hot plate and Haffner’s tail-clip method in rats.
Conclusion: The anti-inflammatory and analgesic effects of methanolic extract may be due to inhibition of the prostaglandin synthesis.
Suhail Ahmad Parra, Kalpesh Gaur, Ashok Dashora, Mohammad Imran Rather. Evaluation of anti-inflammatory and analgesic activity of methanolic extract of Berberis lycium Royle. J Med Plants Stud 2019;7(1):39-45.