2019, Vol. 7, Issue 1, Part A

author(s)
David Segura Cobos, María Elena Martínez Juárez, Guillermina Casas García, Gabriel Martínez Cortés, Elizabeth Alejandrina Guzmán Hernández and Beatriz Vázquez Cruz

abstract
The aqueous extracts of Porophyllum tagetoides and Annona reticulata were investigated for its anti-inflammatory and analgesic activities in animal models. The extracts at 200 and 300 mg/kg reduced significantly the formation of edema induced by carrageenan. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by a significant reduction in the number of writhes with two doses (100 and 200 mg/kg) used when compared to the untreated control group. Indomethacin at 10 mg/kg served as reference drug in all these tests. Moreover, P. tagetoides and A. reticulata also remarkably suppressed carrageenan-induced peritoneal leukocyte migration in rats. These results demonstrate that P. tagetoides and A. reticulata present remarkable anti-inflammatory activity, which supported its traditional use in the treatment of various diseases associated with inflammation.