Guazuma ulmifolia, Lam. known as West Indian elm or bay cedar, native of tropical America is been cultivated in India since a century. It contains alkaloids, tannins, saponins, flavanoids, terpenoids, cardiac glycosides and steroids. Isolation of octacosanol, taraxeroloac, friedelin-3-áoac, â-sitosterol, and Friedelinol-3-acetate in the leaves are reported. Heartwood contains kaempferol and fruit contains the sweet edible mucilage. Its essential oil is contains major compound Eugenol (10.13%). The isolation of epicatechin and procyanidins oligomers such as procyanidin B2, procyanidin B5, procyanidin C1 from bark is reported.Ethnobotanical uses of G. ulmifolia of the leaves, bark, fruit, root, stem bark are reported for properties like antidysenteric, antibacterial, anti-inflammatory, antimicrobial, antifungal astringent, depurative, diaphoretic febrifuge, emollient, hepatoprotective, Pectoral, stomachic, styptic, sudorific, refrigerant and vulnerary. The pharmacological evaluations on plant demonstrated till date are Antioxidant, Antihypertensive and Vasorelaxing Activity, Antidiabetic, Antiviral, Ant secretory, Antibacterial, Antifungal, Cytotoxicity, Gastro protective, Hepatoprotective, Neurological & Uterine stimulant activity. The purpose of this manuscript is to bring into focus the plant G. ulmifolia for exploring its multipurpose uses. Thus, Ethnopharmacology suggests several medicinal uses out of which antiviral, antibacterial, antidiabetic and gastro protective are yet to be scientifically proven.