David Segura Cobos, María Luisa Nieto López, Elizabeth Alejandrina Guzmán Hernández and Beatriz Vázquez Cruz
This paper aimed to test whether the extracts of Heimia salicifolia leaves contract isolated uterus of estrogenized rats. H. salicifolia (Lythraceae) is a shrub used in traditional medicine as abortifacient in Mexico. Leaves of H. salicifolia were extracted with water, methanol and chloroform. Uterotonic activity was studied in the isolated uterus of Wistar female rats, previously oestrogenized with diethylstilbestrol (l mg/kg, sc). After 24 h the uterus was obtained and placed in an isolated organ chamber with constant bubbling of a mixture of 02/C02 95:5. 30 °C. Concentration-response curves were performed to oxytocin (Control), aqueous and methanolic extracts. Maximum response to oxytocin was observed with 0.8 ng/ml, to aqueous extract with 450 mg/ml and methanolic extract with 271. l mg/ml. Chlorofom extract (l08 mg/ml) showed uterotonic effect and was inhibited with indomethacin. Heimia salicifolia showed oxytoxic activity and explain their use in traditional medicine as abortifacient.