Assessment of analgesic and neuropharmacological activity of ethanol leaves extract of Gynura procumbens (Family: Asteraceae)
Latifa Akter, Sharmin Sultana and Md. Lokman Hossain
Background:Gynura procumbens belonging to Asteraceae family is a medicinal plant commonly found in tropical Asian countries such as Bangladesh, India, China, Thailand, Indonesia, Malaysia, and Vietnam. Traditionally, it is widely used in many different countries for the treatment of a wide variety of health ailments such as kidney discomfort, rheumatism, diabetes mellitus, constipation, and hypertension. Based on the traditional uses of G. procumbens, it seems to possess high therapeutic potential for treatment of various diseases making it a target for pharmacological studies aiming to validate and provide scientific evidence for the traditional claims of its efficacy. As part of our ongoing research of traditional medicinal plant, this study evaluated the analgesic and neuropharmacological activity of Ethanol Extract of Gynura procumbens (EEGP)leaves. Method: The analgesic effect of EEGP was determined by acetic acid induced writhing test, tail immersion test and hot plate test using swiss albino mice as experimental animal. Open field and hole cross test were used to determine the neuropharmacological activity of EEGP. Result: Preliminary phytochemical screening revealed the presence of tannin, flavonoids, steroids, glycoside, alkaloids and terpenoids. The present study demonstrated that EEGP showed significant analgesic (p<0.05) effect at the dose level of 200 and 400 mg/kg body weight in acetic acid induced writhing test, tail immersion test and hot plate test. EEGP decreased the movement of mice significantly at the doses of 200 and 400 mg/kg body weightin open field and hole cross test. Conclusion: The present study indicates that EEGP possess analgesic and neuropharmacological activity in a dose-dependent manner. Hence, the present work was undertaken to evaluate and co-relate the bioactivity with the traditional uses of G. procumbens. So, the plant may be further subjected to chemical investigation to isolate the bioactive compound(s) responsible for its pharmacological activity.