Oral glucose tolerance test with methanolic extract of Zingiber montanum Link ex A. Dietr. (Zingiberaceae) flowers
Khoshnur Jannat, Rownak Jahan and Mohammed Rahmatullah
Zingiber montanum or cassumunar zinger is a common ginger species in Asia, which has ethnic uses against various ailments like headache, dysentery, constipation, skin diseases, inflammation, jaundice, dyspepsia, pain, ulcer, fever and common cold. The objective of the study was to evaluate the antihyperglycemic effect of methanol extract of flowers of the plant, which is used by the Marma tribe in the Bandarban area of Bangladesh to keep high blood glucose level under control. Antihyperglycemic activity was determined through oral glucose tolerance test (OGTT) with methanol extract of Zingiber montanum flower. The extract (MEZM) at doses of 50, 100, 200, and 400 mg per kg body weight each to glucose-loaded mice reduced blood glucose levels by 13.6, 21.8, 27.9, and 32.3%, respectively, compared to control (untreated) mice. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by40.8%. Our results validate the use of flowers by the Marma tribe to lower elevated blood glucose levels.
Khoshnur Jannat, Rownak Jahan, Mohammed Rahmatullah. Oral glucose tolerance test with methanolic extract of Zingiber montanum Link ex A. Dietr. (Zingiberaceae) flowers. J Med Plants Stud 2020;8(3):85-88.