Effect of the leaf extracts of Funtumia africana (Benth.) Stapf. against selected pathogens
Bamidele M Amos-Tautua, Kazeem A Alayande, Olusiji Ajileye, Olatomide A Fadare, Adebayo Onigbinde and Sandile P Songca
This study investigates the phytochemical and antimicrobial properties of the leaf extracts of Funtumia africana. Powdered leaves of F. africana were extracted with 20 % aqueous methanol, concentrated in vacuo and successively extracted with different solvents. The most active n-hexane fraction was further profiled using FTIR and GC-MS. Effectiveness of the extracts against microorganisms was assessed using agar dilution methods. Phytochemical analysis revealed the presence reducing sugars, alkaloids, terpenoids, steroids, tannins, flavonoids and cardiac glycosides. The ethyl acetate and n-hexane fractions displayed MIC values of ≤ 0.63 mg/ml against 53% and 82% of the test pathogens respectively and exhibited the lowest MBC value (0.63 mg/ml) against Staphylococcus aureus and Klebsiella pneumoniae, respectively. GC-MS analysis reveals the presence of methyl hexadecanoate at 45.96% and 6,10,14 trimethyl-2-pentadecanone at 17.10% as well as n-hexadecanoic acid/palmitic acid (14.12%), methyl stearate (10.14%) and (Z,Z)-9,12-octadecadienoic acid/linoleic acid (2.09%). Results from this study demonstrate that the leaf of F. africana could be a good source of antibiotic agents with broad spectrum.
Bamidele M Amos-Tautua, Kazeem A Alayande, Olusiji Ajileye, Olatomide A Fadare, Adebayo Onigbinde, Sandile P Songca. Effect of the leaf extracts of Funtumia africana (Benth.) Stapf. against selected pathogens. J Med Plants Stud 2020;8(4):125-129.