Ayurveda the Indian traditional medicinal system evidences that the utilization of spices provides better human health and cures various diseases. Some of the scientific reports also have been proven the beneficial effects of spices in humans. Many Indian spices primarily used for the culinary purpose and have been found to have reported specific activity against CNS disorders. This review focuses on the Indian spices black cumin, cardamom, coriander, fennel, garlic, saffron, and turmeric therapeutic applications and it's till date scientific findings in CNS disorders. The review findings of this study suggest that these Indian spices possess therapeutic potential in disorders associated with neuroinflammation, neurotransmitter deficiency, and depression. It might be due to their phytoconstituents and potent antioxidant properties.