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Journal of Medicinal Plants Studies
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ISSN Print: 2394-0530, ISSN Online: 2320-3862, NAAS Rating: 3.53

NAAS Rating: 3.53 NEW

Journal of Medicinal Plants Studies

2020, Vol. 8, Issue 4, Part C
Effects of aqueous extract of root barks of Swartzia madagascariensis (Caesalpiniaceae) on acute kidney failure induced with gentamicin in Wistar rats

André Perfusion Amang, Odile Baponwa, Christophe Mezui, Gael Tchokomeni Siwe, Luc Vandza Vandi, Amstrong Njuh, Hacheked Mbida, Etienne Kodji and Paul Vernyuy Tan

Aim: The aim of this study was to evaluate the nephroprotective effects of aqueous extract of root barks of Swartzia madagascariensis (AERBSM) on acute kidney failure (AKF) induced with Gentamicin in Wistar rats.
Methods: 45 rats were divided into 9 groups of 5 animals: 3 control groups (normal, negative and positive), 4 test groups and 2 satellite groups (control and test). All the animals except normal control received daily doses of gentamicin (80 mg/kg, i.p) during 8 days concomitantly with distilled water (negative and satellite controls), 0.9 % normal saline (positive control), AERBSM at 50, 100, 200 and 400 mg/kg (test groups), and AERBSM 400 mg/kg (satellite test group). Urinary biochemical parameters (pH, leucocyturia, glucosuria, proteinuria, osmolarity), hematological parameters (White and Red Blood Cells counts, Hemoglobin and Platelet counts), serum parameters (creatinine, urea, BUN, ALAT, ASAT, alkaline phosphatase, bilirubin, total cholesterol) and oxidative stress markers (MDA, SOD, CAT, GSH) were evaluated. Histological sections of the liver, kidney and lungs were prepared.
Results: Groups treated with AERBSM showed significant decrease of markers of kidney and liver pathology (urinary, haematological and serum) as compared to the negative control. AERBSM significantly (p<0.01) reduced MDA concentration and increased kidney and liver SOD, CAT and GSH activities compared with the negative control. Histological observation revealed that AERBSM corrected the kidney damage induced by gentamicin.
Conclusion: The observed nephroprotective effects of AERBSM could be related to its antioxidant properties.
Pages : 183-197 | 64 Views | 4 Downloads
How to cite this article:
André Perfusion Amang, Odile Baponwa, Christophe Mezui, Gael Tchokomeni Siwe, Luc Vandza Vandi, Amstrong Njuh, Hacheked Mbida, Etienne Kodji, Paul Vernyuy Tan. Effects of aqueous extract of root barks of Swartzia madagascariensis (Caesalpiniaceae) on acute kidney failure induced with gentamicin in Wistar rats. J Med Plants Stud 2020;8(4):183-197.
Journal of Medicinal Plants Studies
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