in vivo evaluation of anti-inflammatory activities of ethanolic extract of Buchanania lanzan Spreng bark
C Pramod, Dr. Ratheesh M, Svenia P Jose and Feena Paul
The present study was carried out to evaluate the in-vivo anti-inflammatory potential of Buchanania lanzan Spreng used in Indian traditional medication. The sequentially extracted plant sample in ethanol was evaluated for in-vivo anti-inflammatory and antioxidant activities. The in-vivo anti-inflammatory activity of selected samples showing promising inflammatory markers was assessed using the carrageenan (CIP) and Cotton wool granuloma (CWG) method in mice animal models. The results obtained reveal that the ethanolic extract was found carrageenan induced animals treated with EEBL showed a significant reduction in the paw volume at 2nd and 3rd hour after carrageenan induction when compared to the control group. The ethanolic extract of the plant demonstrated an effective total number of leukocytes in the blood of all the cotton wool inserted animals that were recorded on the 0th and 8th day. The data showed that on the 8th day, there should be a highly significant reduction in leukocytes migration on blood analysis. It shows a significant impact on inhibition of edema formation.