2022, Vol. 10, Issue 3, Part A

Objectives: In this study, the endophytic extract of Senna alata was evaluated for its antihelmintic properties in mice.

Method: The leaves of Senna alata were obtained in Ufuma Orumba North Anambra state, were treated with 70% of ethanol for 3 minutes. Malt extract agar was prepared and transferred into several sterilized Petri dishes, allowed to solidify, before inoculation. Local rice used for the fermentation was prepared in several conical flasks by weighing 100g of the rice into each flask and mixing it with 200ml of water. At the end of the 3-day homogenization, the mixtures were decanted into sterile beakers. The filtrate was then concentrated by exposing them to room temperature for 5-7 days. The extracts were then stored at 25 ^oC for further use. The anthelmintic activity was performed according to the method followed by Shelke et al., 2020, albendazole was used as the standard drug.

Result: It showed that the extract paralyzed worms at the same time Albendazole did and that it was more effective at higher concentrations of 50mg/ml.

Conclusion: This plant possesses potent anthelmintic activity in a dose-dependent manner, and may prove useful as a cost-effective and safe anthelmintic alternative.