Evaluation of CNS depressant activity of methanolic extract of Brownlowia tersa leaves in Swiss albino mice
Md. Farhad Hossen, Md. Asrafuzzaman and Md. Abdul Mannan
Brownlowia tersa (Linn.) is called in Bangladesh as "Sundari lata." It's been used as a folk cure for diarrhea, dysentery, sores, and boils for centuries. The goal of this study was to see the methanolic extract of Brownlowia tersa (B. tersa) leaves might depress the central nervous system in Swiss albino mice. Open field, hole cross, force swimming, tail suspension, and thiopental sodium induced sleeping duration tests in mice were used to assess B. tersa's central nervous system depressant activity. The mice were placed into five groups, each of which included five mice. In all behavioral animal models, the plant extract was administered orally at dosages of 50, 100, and 200 mg/kg body weight. All experiments used distilled water (0.1 mL/mouse, p.o.) as a control. The reference drug was diazepam (1 mg/kg, i.p.). In both the open field and hole cross tests, the plant extract significantly reduced locomotor and exploratory behaviors (*p<0.05). The extract caused a considerable increase in immobility time in the forced swimming and tail suspension tests. In addition, the crude extract resulted in a substantial reduction in latency time and an increase in sleeping time length (*p<0.05). The findings imply that the methanolic extract of B. tersa contains active principles that are responsible for the CNS depressing activity in mice. In order to produce novel drugs, more research into the mechanisms of action involved in these pharmacological effects is required.
Md. Farhad Hossen, Md. Asrafuzzaman, Md. Abdul Mannan. Evaluation of CNS depressant activity of methanolic extract of Brownlowia tersa leaves in Swiss albino mice. J Med Plants Stud 2022;10(4):150-155.