Up to 10% of people worldwide are affected by the chronic condition known as Peptic Ulcer. Peptic Ulcer development is influenced by the pH of gastric juice and a decline in mucosal defences. The main factors affecting the mucosal resistance to damage are Helicobacter pylori (H. pylori) infection and non-steroidal anti-inflammatory medicines (NSAIDs). Treatment for Peptic Ulcers is today a challenging task for every patient. A Peptic Ulcer is a digestive disorder that affects the GI tract and results from a disruption of the normal equilibrium brought on by either increased aggression or decreased mucosal resistance. It creates an inflammatory rupture in the epidermis or the mucous membrane lining of the alimentary tract. Today, there are various synthetic medications available to treat ulcers. However, these medications are more expensive than herbal remedies and are likely to have greater adverse effects. The purpose of this overview to discuss about certain medicinal plants that may be utilized in both Ayurvedic and western medicine for the treatment or prevention of Peptic Ulcers.