2023, Vol. 11, Issue 6, Part A

Proteins are fundamental to all biology. Structural biology is the science behind the determination of the three-dimensional structures of these essential molecules and the application of this information to studies of their function and role. Using the tools of computational biology determine composition and relationship of Pentene/Hexene, Chromosome, Gene (DNA/RNA) as follows.

Enumerate and explain the basic hierarchy of protein structure (Pentene/Hexene, Chromosome, Gene (DNA/RNA)), in terms of primary, secondary, tertiary and quaternary structure, motifs and domains

Explain how these structures arise from basic amino acid chemistry and the geometry of the peptide bond

Explain how the structures of membrane-embedded proteins differ from those of soluble ones

Describe in detail the structures of proteins involved in key biological processes including, but not restricted to: DNA expression, enzyme catalysis, oxygen transport and immune function

Analyses how protein structure (Pentene/Hexene, Chromosome, Gene (DNA/RNA)) relates to drug design and how small changes to protein sequence and structure can give rise to disease.

A clear description of the deliverables. A deliverable is the end result of a research project. It could be a report, protocol, new approach, recommendation, technology, software, device, product, etc.

Deliverable 1: New approach to understand the generation mechanism of Pentene/Hexene from atomics, Chromosome.

Deliverable 2: New approach to understand the generation mechanism of Chromosome from Hexene/Pentane.

Deliverable 3: New approach to understand the generation mechanism of Gene (DNA/RNA) from Chromosome.

Why the research approach is state of the art, innovative, and may have a high impact for resilience and metabolic or homeostatic processes as countermeasures for space flight?

Proposed study address fundamental questions that advance the understanding of the microbial ecosystem in the closed environment of the space flight. This investigation is hypothesis-driven research to study the dynamics of microbial communities within the built environment, among different microbial species, or between microbes and plants and/or humans. This investigation will develop models that describe biology and microbial dynamics in the spaceflight environment. Models of the investigation enable the prediction of microbial responses and promote the prevention, monitoring, and treatment/intervention of contamination by potentially harmful microorganisms in the biological environments.